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Ro5-4864, which is also called 4′-chlorodiazepam, is a new drug that is a benzodiazepine version of diazepam. However, unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABAA receptors and lacks typical benzodiazepine effects, instead being sedative yet also convulsant and anxiogenic in effects. Ro5-4864 was found to be a strong ligand for the “peripheral benzodiazepine receptor,” which was later renamed “mitochondrial translocator protein 18kDa” (TSPO). In vitro studies and rodent models also suggest the possibility of analgesic, antidepressant, cardioprotective, and anti-cancer effects.
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