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Ro5-4864, or 4′-chlorodiazepam, is a benzodiazepine derivative of diazepam that has never been used clinically before. Ro5-4864 is a benzodiazepine derivative with effects that are sedative but also convulsant and anxiogenic; this sets it apart from the vast majority of benzodiazepine derivatives. The mitochondrial translocator protein 18kDa (TSPO), formerly known as the “peripheral benzodiazepine receptor,” was revealed to be a strong ligand for Ro5-4864. There is some evidence from in vitro and animal models that it may have analgesic, depressive, cardioprotective, and anticancer properties as well.
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